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The first in the province to break 100, what makes Jiangning so special?

In contrast, it took Frontier Biologics, founded in 2002, a full 16 years to wait for China's first original anti-AIDS drug, Econin®, to be approved for marketing.

This is the world's first long-acting anti-HIV viral fusion inhibitor, which is classified as a Class 1.1 new drug in China.Although the enterprise's plant has long been used for large-scale reactors more than one person high and with a capacity of more than 1,000 liters, vice general manager Zhu Yuting still insists on keeping the palm-sized syringes, oxidized and yellowed more than a decade ago, in the showroom. "Conducting more than 150 scientific studies before and after, this is the hardship of making original new drugs."

In September this year, the provincial Department of Industry and Information Technology announced the sixth batch of national specialties and new "small giants" list of enterprises.Nanjing Jiangning District added 29, totaling 113, becoming the first administrative county in the province to break 100.

Specialized, special new "small giants" enterprises have been focusing on niche markets for a long time, with strong innovation ability and mastery of key core technologies, and have gradually become the front-runners of economic transformation and upgrading, and the main force of innovation drive.

The growth of "small giants" is a microcosm of the forging of "hard core" industrial chain supply chain in Jiangning District.The district in the cultivation of specialized special new enterprises on the target force, the provincial speciality of new small and medium-sized enterprises reached 400, the total amount of more than a quarter of the city of NanjingThe

Leave your comfort zone and dare to sit on the bench

From its establishment in 2020 to becoming a national specialized company this year, the young CLP Pengcheng Intelligent Equipment Co. has only used 4 years. However, the related technical team began to accumulate 27 years ago.

In 1997, a Shenzhen company under the China Electronics Corporation set up an automation division and invested nearly 30 million yuan annually to develop a half-finger-sized hard disk head. 2015, in response to the national smart manufacturing strategy, China Electronics Corporation launched the "Manufacturing Capability Enhancement Project", and the former Shenzhen Science and Technology Corporation's technical team set up the CLP Peng Cheng. China Electronics

With the aura of a third-tier subsidiary of a centralized enterprise, CLP Pengcheng chose the unfamiliar new track - chip defect detection.Due to the high technical threshold, this field has long been controlled by European and American enterprises, and domestic enterprises rarely "probe". This means that the team has to start from scratch.

The enterprise registered capital of 100 million yuan, in accordance with the "staff and management shareholding 15%" mixed ownership reform program, the first year will be able to have more than 10 million yuan of profit."But in the first two years, we decided not to pay dividends for a while, but to continue to spend on research and development, and no one complained."Zhang Zhiyong, vice chairman of CLP Pengcheng, said.

After two years of start-up "only get paid", the team launched the first chip defect detection machine in 2022, and passed the national high-tech enterprise certification in the same year."In fact, as long as a slight reversal of direction, back to the 'comfort zone', you can launch the energy production, earn quick money of other equipment, but we still choose to sit on the 'bench'." Zhang Zhiyong frankly.

In contrast, it took Frontier Biologics, founded in 2002, a full 16 years to wait for China's first original anti-AIDS drug, Econin®, to be approved for marketing.

This is the world's first long-acting anti-HIV viral fusion inhibitor, which is classified as a Class 1.1 new drug in China.Although the enterprise's plant has long been used for large-scale reactors more than one person high and with a capacity of more than 1,000 liters, vice general manager Zhu Yuting still insists on keeping the palm-sized syringes, oxidized and yellowed more than a decade ago, in the showroom. "Conducting more than 150 scientific studies before and after, this is the hardship of making original new drugs."

Tianfushu Software also chose to "ask for trouble" and anchored itself to CAE, the "crown jewel" of the industrial software field."It needs to span multiple disciplines such as math, physics, mechanics and computer science. In addition this development process is long term and requires many iterations and upgrades to reach the desired state. A rush mentality is not suitable for this field." Jasmine Xie, Director of Corporate R&D, said bluntly.

The market share of domestic software is only 5%, and domestic customers are not willing to take the risk of switching to foreign software even if they buy it at a high price. 2011, Tianfushu Software was founded in such a market environment.

No one else has what I have, and I'm committed to cultivating my inner strength.

Dedicated to cultivate "internal strength", forging "unique skills", is the common point of specialization and special new enterprises coincide.

Before the launch of the first high-precision intelligent PCBA vision inspection machine, CLP sent a three-member team to the customer's factory to test the prototype. After months of testing and improvement, loaded with hundreds of silicon carbide chips, the material board can be 20 G acceleration, take turns "rushing" through the detection equipment and active braking.Micron-level positioning technology instantly locks in appearance, size, performance and other imperfections with a fineness equivalent to one thousandth of a hair.

With this technical advantage, the product in May last year through the provincial scientific and technological achievements evaluation, the expert group unanimously agreed that it "belongs to the PCBA final inspection link of the first set of domestic, the overall technology is at the international advanced level"."Sometimes we have to thank the West, they block the road and we go on our own. The Chinese are smart and hardworking and not afraid of that."Zhang Zhiyong said.

Yuting Zhu is deeply convinced of this. In the last five years before Ekornin® was launched, the team traveled 460,000 kilometers across six provinces and 13 cities in China in order to find the widest range of different patient populations to conduct clinical trials, especially during clinical phase III, when it took the initiative to increase the number of docking hospitals from 12 to 19 that had the qualification for clinical research.

As the HIV virus gets "smarter", the global "cocktail of therapies" is becoming increasingly ineffective against infected immune cells that can replicate the new virus.Aiming at this worldwide problem, Ekornin directly intervenes in the first stage of viral infection by inhibiting the fusion of viral membranes with human cell membranes.

"The leading companies have diversified business lines, and with a slight layout of a new track, they can soon crush a small business. That's all the more reason for us to cultivate our core competitiveness and achieve 'no one has what I have' in niche areas." Zhu Yuting said.

Currently, Econium® has opened up two modes of administration, intravenous infusion and intravenous push, breaking the market status quo of traditional oral administration in one fell swoop. In addition, it is administered once a week and has a long half-life of 11 to 12 days in the human body, which is substantially longer than the 2-3 hours of general peptide drugs.The company is also exploring its application to long-acting antiviral regimens administered every four weeks.

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