S&G's S&G Hawkeye® Early Tumor Screening product can screen nine types of highly prevalent cancers, including lung, liver, and intestinal cancers, at one time with just one tube of blood;
○ Zenmax's SURFSeq Q ultra-high-throughput gene sequencer can produce up to 9Tb in a single day, which is equivalent to sequencing the whole genome of more than 23,000 people per year;
○ The chip-based large-field-of-view superstructure microscope of NZCV is only the size of a rechargeable treasure, but the imaging field of view can be up to 7-10 times larger than that of traditional equipment, which can be used for high-throughput observation of laboratory tests and diagnosis of disease foci.
character used in Taiwan as a substitute for a real name (like "X" in English) Some organizations predict that the current total potential market size of the global gene industry is 242.5 billion yuan, and the market size of cell therapy drugs in China will grow from 1.3 billion yuan in 2021 to 58.4 billion yuan in 2030.
○ Jiangbei New Area genes and cellular technology was included in the province's first batch of future industry first agglomeration development pilot, in fact, many of the "genes" here have gone to the industry "peak".01Four worldwide, one in NanjingIn October last year, Shiho One® Tumor Mutation Load Detection Kit [GuoMeZhiQi 20233401452] was approved through the innovative medical device program, which can detect more than 400 genes in a single test, filling the blank of domestic large panel genetic testing products, and it is the only domestic "innovative" reagent product that will be listed on the market in 2023, and it is the only domestic "innovative" reagent product. It is the only domestic "innovative" reagent product to be marketed in 2023.At this point, Shihe Genetics has become the only company with two innovative NGS kit products in the oncology precision medicine industry.
In December last year, Shiho CanScan®, a multi-cancer early screening product independently developed by Shiho Genetics and based on MERCURY multi-omics liquid biopsy technology, was recognized as a breakthrough medical device by the U.S. FDA. Currently, there are only four multi-cancer early screening products in the world that have obtained this certification, and Shiho Hawkeye® is the early screening product with the most comprehensive coverage of cancer types and the widest range of screening in China that has obtained this certification.
○Gene and cell technologies have great market potential in the life and health field, and their emerging disruptive technologies are providing strong protection for people's life and health.
○ Traditional methods of early cancer screening include imaging tests, tumor marker tests, and tissue biopsies, which usually suffer from long preparation time, invasiveness, and limited accuracy.
And Sei and Hawkeye.®The early tumor screening product, which uses the MERCURY multi-omics liquid biopsy technology, can screen nine types of highly prevalent cancers, including lung, liver, and intestinal cancers, in one go, with just one tube of blood.Once abnormal signals are detected, Seiwa Hawkeye® can also locate the specific site of the signal's origin, thus significantly shortening the time and process of tumor screening.
○"Understanding the most urgent clinical problems is what we always focus on in the R&D process." Wang Xiaonan, co-founder and chief technology officer of Nanjing Shihe Gene Biotechnology Co., Ltd, said that Shihe's products have expanded from facilitating the precise use of drugs in the late stage of cancer and the assessment of the risk of recurrence in the early and mid-stage to early screening, realizing the full range of products from "early" to "late". The product has been expanded to early screening, realizing the whole line from "early" to "late".
character used in Taiwan as a substitute for a real name (like "X" in English) In 2022, Shiho Genetics, together with Nanjing Jiangbei New District and Nanjing Medical University, launched the "Jinling Cohort" large-scale public welfare project for early tumor screening of natural populations, with a plan to provide free medical checkups for 100,000 Nanjing citizens aged 45-75 for a period of three years, and to validate the performance of Shiho Hawkeye® for early screening at the same time.At present, the program has provided free medical checkups for 15,000 residents of Nanjing Jiangbei New District. The data up to now shows that Shiho Hawkeye® has demonstrated world-leading excellence in the field of multi-cancer early screening.
02How high is "super high"?○ SURFSeq Q ultra-high-throughput gene sequencer, the word "ultra-high" directly expresses the important characteristics of this device."In addition to the ultra-high assay data throughput, this product has a very high sequencing accuracy of over 99.951 TP3T."Zhou Zhiliang, president and co-founder of Zenmax Bio, introduced that the main application scenarios of the product are in large-scale scientific research projects, which require a high degree of accuracy.
○Gene sequencer, or DNA sequencer, is an instrument that determines the order, type, and quantification of the bases of DNA fragments. Globally, gene sequencing technology and products have been widely used in various medical and scientific research fields, and various application scenarios are still being developed. However, this promising track has long been dominated by overseas products.
12 years ago, Zenmax Bio started from zero, focusing on the self-development and self-production of gene sequencers. Gene sequencer is a multidisciplinary and complex system, when Zenmax was founded, the domestic products, technology accumulation and talent chain were almost all blank.
Today, Zenmax has become the only company in the world that can produce full arrays from small throughput, medium throughput, high throughput to ultra-high throughput.
Nanjing Zenmax Biotechnology Co., Ltd. is Zenmax Biotechnology's first subsidiary outside of its headquarters in Shenzhen, and Nanjing is taken as Zenmax Biotechnology's R&D center, manufacturing center, and marketing support center in East China.
○ "Before product development, we do very deep communication of user needs, and there will be a specialized team responsible for researching a large number of user units including enterprises and research institutions." Zhou Zhiliang introduced that, demand-oriented, Zenmax Bio's products have realized the full coverage of small throughput, medium throughput, high throughput and then ultra-high throughput, with different products corresponding to different applications.
○ Like the latest SURFSeq Q ultra-high-throughput gene sequencer, it can meet the needs of large cohort population testing, spatial genomics research, and agricultural breeding. And some small model products can meet the needs of time-sensitive and flexible requirements such as infection detection, and the results can be available in 3-4 hours.
○ "This year has been the third year for Zenmax Bio to break into the overseas market, we have established cooperation with more than 50 countries and regions around the world, and the overseas market accounts for more than 30% of revenue." Zhou Zhiliang said.03"Photovoltaic" for a stronger futureIt is the size of a rechargeable treasure, with a jack at the top, and can be directly connected to related devices through a data cable. This is the chip-type large field of view superstructure microscope of Nanzhi CoreVision (Nanjing) Technology Co., Ltd. and its imaging field of view can reach 7-10 times of the field of view range of traditional commercial microscopes with the same resolution.
Ltd. is one of the enterprises incubated by NII Advanced Optoelectronic Integration Technology Research Institute. The chip-type large-field-of-view superstructure microscope is an industrialized product based on the research results of Prof. Tao Li's team from the School of Modern Engineering and Applied Science of Nanjing University.
character used in Taiwan as a substitute for a real name (like "X" in English) This highly integrated chip-based superstructure microscope is listed in the Important Achievements and Ten Major Advances in Chinese Optics."With its small size and strong imaging performance, the core imaging component is only on a 'chip' scale, which can be used as an important core module that is very flexible and applicable to imaging and detection instrumentation in various environments, such as microendoscopy, microfluidic cell counting, and pathology scanning, to meet the needs of high-throughput observational assays and lesion diagnosis." Mr. Cheng Zhaoyu, General Manager of Nanzhi CoreVision, said.
For future industries that have to continue to seek technological breakthroughs, cutting-edge technology research and the transformation of scientific and technological achievements are crucial.Jiangbei New District to build photoelectric technology innovation center, national health care big data (East) center and a number of other major science and innovation platforms, for enterprise research and development, results transformation, industrialization cooperation, to provide a full range of support and assistance.
○ Many enterprises suggested that the application of artificial intelligence in gene and cell technology is promising, and with the help of science and innovation platforms such as Nanzhi Optoelectronics, they can accelerate the innovative exploration of technological cross-fertilization.
character used in Taiwan as a substitute for a real name (like "X" in English) Nanjing Qi Carbon Technology Co., Ltd, which just landed in Jiangbei New District last year, is running to the production line platform of Nanzhi Optoelectronics. Qicarbon Technology has independently developed the first commercialized nanopore gene sequencer in China, and the palm-sized sequencer can realize gene sequencing anytime, anywhere.Qicarbon Technology chose to cooperate with Nanzhi Optoelectronics after various inspections, utilizing the technology and services of advanced photonic chip production lines for the development and product iteration of nanopore sequencing chips, and has achieved excellent results at a stage.
Not long ago, the Ministry of Education and the People's Government of Jiangsu Province signed an agreement to build the first national university regional technology transfer center. Among them, the Nanjing Biomedical Sub-center is located in the Biomedical Valley of Jiangbei New District. The sub-center will create a "dual center" for the transformation of scientific and technological achievements of universities and the training of innovative and entrepreneurial talents, and open a new channel for the biomedical industry, including gene and cell technology, to "research and production through".
character used in Taiwan as a substitute for a real name (like "X" in English) At present, Jiangbei New Area has gathered more than 40 cell and gene technology innovation enterprises, and has initially constructed a cell and gene technology industry chain from gene testing, diagnosis and reagents to mouse gene editing, antibody drugs, immune cell therapy, CAR-T cell therapy and targeted drugs, and the industrial ecology and cluster effect has begun to emerge.
○It is foreseeable that in the future, a number of new technologies and products will come to the "top" of the industry, bringing new hope for life and health.